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  • Title: Regulation and functions of Rho-associated kinase.
    Author: Amano M, Fukata Y, Kaibuchi K.
    Journal: Exp Cell Res; 2000 Nov 25; 261(1):44-51. PubMed ID: 11082274.
    Abstract:
    Remarkable progress has been made in understanding effector molecules of small GTPase Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho-associated kinase appears to mediate a large proportion of the signals from Rho and regulate dynamic reorganization of cytoskeletal proteins, such as stress fiber and focal adhesion formation. Several substrates of Rho-associated kinase have been reported and their cellular functions unraveled. In this review, we focus on the regulation and cellular functions of Rho-associated kinase.
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