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  • Title: [Vertebrate galectins: structure and function, role in tumoral process].
    Author: Bassen R, Brichory F, Caulet-Maugendre S, Delaval P, Dazord L.
    Journal: Bull Cancer; 2000 Oct; 87(10):703-7. PubMed ID: 11084533.
    Abstract:
    Galectins are proteins structurally related to the lectin family. They share, with lectins, the ability to bind carbohydrate residues. Galectins are suspected to mediate several biological functions such as embryonic development growth, immune response and apoptosis. Their role is similar to that of adhesion molecules in cell to cell or to matrix interactions. Their contribution to human carcinogenesis has been suggested from experimental studies. In clinical research, they could be used as a differentiation marker, particularly in thyroid carcinomas and in certain lymphomas.
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