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  • Title: Identification of a K(d)-restricted antigenic peptide encoded by murine cytomegalovirus early gene M84.
    Author: Holtappels R, Thomas D, Reddehase MJ.
    Journal: J Gen Virol; 2000 Dec; 81(Pt 12):3037-3042. PubMed ID: 11086134.
    Abstract:
    The two sister cytomegaloviruses (CMVs), human and murine CMV, have both evolved immune evasion functions that interfere with the major histocompatibility complex class I (MHC-I) pathway of antigen processing and presentation and are effectual in the early (E) phase of virus gene expression. However, studies on murine CMV have shown that E-phase immune evasion is leaky. An E-phase protein involved in immune evasion, namely m04-gp34, was found to simultaneously account for an antigenic peptide presented by the MHC-I molecule D(d). Recent work has demonstrated the induction of protective immunity specific for the E-phase protein M84-p65, one of two murine CMV homologues of the human CMV matrix protein UL83-pp65. In this study, the identification of the MHC-I K(d)-restricted M84 peptide (297)AYAGLFTPL(305) is documented. This peptide is the third antigenic peptide described for murine CMV and the second that escapes immunosubversive mechanisms.
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