These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Searching for alternatives to heparin: sulfated fucans from marine invertebrates.
    Author: Mourão PA, Pereira MS.
    Journal: Trends Cardiovasc Med; 1999 Nov; 9(8):225-32. PubMed ID: 11094330.
    Abstract:
    We describe a variety of sulfated polysaccharides with regular and well-defined structures which are useful tools for elucidating structure/biological function relationship. Several of these compounds have anticoagulant and antithrombotic activities. The most studied and promising polysaccharide is a fucosylated chondroitin sulfate, composed of a chondroitin sulfate-like backbone, substituted at position 3 of the beta-D-glucuronic acid with heavily sulfated fucose side chains. The anticoagulant activity of this polysaccharide is mediated by both antithrombin and heparin cofactor II; it has antithrombotic activity when targeted at the intrinsic coagulation pathway.
    [Abstract] [Full Text] [Related] [New Search]