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  • Title: Chloroprocaine-bupivacaine sequence for obstetric extradural analgesia.
    Author: Villa EA, Marx GF.
    Journal: Can Anaesth Soc J; 1975 Jan; 22(1):76-8. PubMed ID: 1109709.
    Abstract:
    Two case reports, one a vaginal delivery, the other a Caesarean Section, have been presented to demonstrate the rationale of employing a chloroprocaine-bupivacaine sequence for extradural analgesia in obstetrics. Use of chloroprocaine for initiation and bupivacaine for maintenance of the block offers at least three advantages: (1) onset of pain relief is prompt while duration is prolonged; (2) more than one "test" dose of chloroprocaine may be employed with safety in rapid succession; (3) two drugs with different metabolic patterns are used, each in reduced amount.
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