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  • Title: Feigrisolides A, B, C and D, new lactones with antibacterial activities from Streptomyces griseus.
    Author: Tang YQ, Sattler I, Thiericke R, Grabley S, Feng XZ.
    Journal: J Antibiot (Tokyo); 2000 Sep; 53(9):934-43. PubMed ID: 11099227.
    Abstract:
    Four new lactone compounds, named feigrisolides A to D (1 to 4), have been isolated from Streptomyces griseus. The chemical structures were determined by detail analysis of their spectroscopic data and chemical transformations. Structurally, the feigrisolides A (1) and B (2) are hepta-lactones, feigrisolide C (3) and D (4) are 16-membered macrodiolides. Biological studies showed that feigrisolide B (2) exhibited strong antibacterial, as well as medium cyctotoxic, and antiviral activities. Feigrisolides A (1), C (3) and D (4) are medium inhibitors of 3alpha-hydroxysteroid-dehydrogenase (3alpha-HSD) inhibiting activity.
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