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  • Title: Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients.
    Author: Llano I, González J, Caputo C, Lai FA, Blayney LM, Tan YP, Marty A.
    Journal: Nat Neurosci; 2000 Dec; 3(12):1256-65. PubMed ID: 11100146.
    Abstract:
    The cellular mechanisms responsible for large miniature currents in some brain synapses remain undefined. In Purkinje cells, we found that large-amplitude miniature inhibitory postsynaptic currents (mIPSCs) were inhibited by ryanodine or by long-term removal of extracellular Ca2+. Two-photon Ca2+ imaging revealed random, ryanodine-sensitive intracellular Ca2+ transients, spatially constrained at putative presynaptic terminals. At high concentration, ryanodine decreased action-potential-evoked rises in intracellular Ca2+. Immuno-localization showed ryanodine receptors in these terminals. Our data suggest that large mIPSCs are multivesicular events regulated by Ca2+ release from ryanodine-sensitive presynaptic Ca2+ stores.
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