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  • Title: Hydroxynitrile lyases in stereoselective catalysis.
    Author: Effenberger F, Förster S, Wajant H.
    Journal: Curr Opin Biotechnol; 2000 Dec; 11(6):532-9. PubMed ID: 11102786.
    Abstract:
    (R)- as well as (S)-cyanohydrins are now easily available as a result of the excellent accessibility, the relatively high stability and the easy handling of hydroxynitrile lyases (HNLs). The optimization of reaction conditions (solvent, temperature, and using site-directed mutagenesis, etc.) has enabled HNL-catalyzed preparations of optically active cyanohydrins on a technical scale. The enantioselectivity of chiral metal-complex-catalyzed additions of trimethylsilyl cyanide to aldehydes has been improved, but is, by far, not yet competitive with the HNL-catalyzed reactions.
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