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  • Title: Dynamic resolution and stereoinversion of secondary alcohols by chemo-enzymatic processes.
    Author: Azerad R, Buisson D.
    Journal: Curr Opin Biotechnol; 2000 Dec; 11(6):565-71. PubMed ID: 11102790.
    Abstract:
    To overcome the maximum 50% yield limitation of classical resolution methods, deracemization processes involving a racemization step (dynamic resolution) or a prochiral intermediate (stereoinversion) have been developed. The use of transition metal complexes as racemizing agents, in combination with an enzymatic reaction, has been successfully extended to the deracemization of a number of simple or functionalized sec-alcohols. A two-enzyme process has been also investigated for their sequential or simultaneous deracemization. Other prominent results arise from an (apparently general) oxidoreduction process catalyzed by a single whole-cell microorganism.
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