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  • Title: Female urethral adenocarcinoma arising from urethritis glandularis.
    Author: Chan YM, Ka-Leung Cheng D, Nga-Yin Cheung A, Yuen-Sheung Ngan H, Wong LC.
    Journal: Gynecol Oncol; 2000 Dec; 79(3):511-4. PubMed ID: 11104631.
    Abstract:
    INTRODUCTION: Female urethral adenocarcinoma is extremely rare and more than one tissue of origin has been suggested other than the Skene's gland. Immunohistochemistry with cytokeratins (CK) 7 and 20 is used to define the origin of the tumor. CASE REPORT: A 72-year-old woman presented with a 2-cm polypoid tumor at the external urethral meatus and bleeding. Wide local excision and bilateral inguinal lymphadenectomy were performed. Postoperative convalescence was uneventful. It was a poorly differentiated mucinous adenocarcinoma without direct urothelial involvement. There were focal areas of intestinal metaplasia. The tumor cells were positive for CK 7 and 20 and negative for prostate-specific antigen. DISCUSSION: This case provides supportive evidence that mucinous urethral adenocarcinoma may arise from malignant transformation of urethritis glandularis.
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