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  • Title: [Free intracellular magnesium in myocardium--measurement and physiological role--state of the art].
    Author: Köppel H, Gasser R, Spichiger U.
    Journal: Wien Med Wochenschr; 2000; 150(15-16):321-4. PubMed ID: 11105326.
    Abstract:
    Magnesium is an important intracellular cation which is known to participate in over 300 biochemical reactions of the cell. Most of the cell's Mg2+ is bound to intracellular structures, and only 5% of the total Mg2+ are unbound and thus biologically active. Clinical data concerning the therapeutic value of Mg2+ in various conditions like myocardial infarction are conflicting, experimental support for a specific therapy is still lacking, because values of free intracellular myocardial Mg2+ as well as behaviour of (Mg2+)i during ischemia or changes of extracellular ion-concentrations have not been elucidated as yet. Various techniques like Mg2+ sensitive dyes, nuclear magnetic resonance spectroscopy or Mg2+ selective microelectrodes have been employed, each of these techniques, however, harbours serious limitations.
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