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  • Title: Alterations of the AML1 transcription factor in human leukemia.
    Author: Downing JR, Higuchi M, Lenny N, Yeoh AE.
    Journal: Semin Cell Dev Biol; 2000 Oct; 11(5):347-60. PubMed ID: 11105899.
    Abstract:
    The identification of clonal chromosomal translocations in human leukemias provided one of the first insights into the underlying pathogenesis of this clinically heterogeneous disease. Over the last decade a large number of these chromosomal rearrangements have been molecularly cloned and the involved genes identified. A surprising finding that has emerged from this work is that many of these chromosomal alterations target the genes encoding the AML1/CBFbeta transcription factor complex, a critical regulator of normal hematopoiesis. In this review, we summarize our present understanding of the mechanisms through which alterations of AML1/CBFbeta contribute to leukemogenesis.
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