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  • Title: Complex rearrangement of chromosomes 6 and 11 as the sole anomaly in atypical teratoid/rhabdoid tumors of the central nervous system.
    Author: Lopez-Gines C, Cerda-Nicolas M, Kepes J, Donat J, Gil-Benso R, Llombart-Bosch A.
    Journal: Cancer Genet Cytogenet; 2000 Oct 15; 122(2):149-52. PubMed ID: 11106829.
    Abstract:
    Atypical teratoid/rhabdoid tumor of the central nervous system is a rare childhood tumor with a distinct histologic appearance and an aggressive clinical course. Few tumors have been analyzed cytogenetically. The only consistent chromosomal abnormality identified in some of these tumors has been monosomy or deletions of chromosome 22; in others, a normal chromosome 22 was present. The authors report an atypical teratoid/rhabdoid neoplasm of the central nervous system with a novel complex rearrangement affecting chromosomes 6 and 11 as the sole anomaly. The involvement of region 11p15 could be important in the pathogenesis of this entity.
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