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  • Title: [Adult height of patients after long-term treatment of idiopathic growth hormone deficiency. (Czech Registry 1991-1998)].
    Author: Zapletalová J, Lebl J, Janstová V, Kalvachová B, Novotná D, Philippiová O.
    Journal: Cas Lek Cesk; 2000 Aug 30; 139(17):529-32. PubMed ID: 11109285.
    Abstract:
    BACKGROUND: Final height was evaluated in patients from the Czech Register with idiopathic growth hormone deficiency treated with GH. METHODS AND RESULTS: 23 patients had the isolated growth hormone deficiency (group 1), and 37 suffered from multiple pituitary hormones deficiencies (group 2). The patients from group 1 and 2 were given growth hormone for 6.7 +/- 2.2 years and 9.6 +/- 3.0 years, respectively. The patients with isolated growth hormone deficiency reached final height -1.4 +/- 1.3 SDS, those with multiple hormone deficiencies were taller (-0.7 +/- 1.5 SDS). The height gain equalled +2.5 +/- 0.6 SDS and +3.4 +/- 1.1 SDS in group 1 and 2, respectively. 70% of the patients in group 1 and 93% of group 2 reached final heights within the target limits (+/- 2 SDS). CONCLUSION: The final height positively correlated with the target height (mid-parental height) and height at the onset of puberty (group 1 and 2). There was a negative correlation between the final height and the chronological age at the beginning of growth hormone therapy in group 1.
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