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  • Title: 5-methyltetrahydrofolic acid is not a methyl donor for biogenic amines: enzymatic formation of formaldehyde.
    Author: Meller E, Rosengarten H, Friedhoff AJ, Stebbins RD, Silber R.
    Journal: Science; 1975 Jan 17; 187(4172):171-3. PubMed ID: 1111095.
    Abstract:
    Contrary to previous reports, 5-methyltetrahydrofolic acid does not mediate the methylation of dopamine to epinine. Instead, this methyl donor is degraded enzymatically to formaldehyde, which condenses with dopamine to form a tetahydoisoquinoline derivative. The latter has chromotographic characteristics very similar to those of epinine, which likely accounts for the original misidentification of the product.
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