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  • Title: 2,3-diphosphoglycerate: a physiological inhibitor of platelet aggregation.
    Author: Iatridis SG, Iatridis PG, Markidou SG, Ragatz BH.
    Journal: Science; 1975 Jan 24; 187(4173):259-61. PubMed ID: 1111100.
    Abstract:
    2,3-Diphosphoglycerate (2,3-DPG) may inhibit the platelet release reaction and the irreversible aggregation of human blood platelets induced by adenosine diphosphate, epinephrine, or norepinephrine. The effects of 2,3-DPG on platelet aggregation were more pronounced in cases with low hematocrit (less than 30 percent). Dipyridamole and vincaminor potentiated the antiaggregating effect of 2,3-DPG. Erythocytes (10-3 to 10-4 per microliter) exhibited a similar antiaggregating effect, especially when secured from anemic patients.
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