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  • Title: Mutagenesis studies on the iron binding ligands of clavaminic acid synthase.
    Author: Doan LX, Hassan A, Lipscomb SJ, Dhanda A, Zhang Z, Schofield CJ.
    Journal: Biochem Biophys Res Commun; 2000 Dec 09; 279(1):240-4. PubMed ID: 11112446.
    Abstract:
    Mutagenesis studies on conserved histidine residues identified as possible metal binding ligands in clavaminic acid synthase isozyme 2 were consistent with His-145 and His-280 acting as iron ligands, in support of crystallographic and previous mutagenesis studies. Mutagenesis of the four cysteines and a glutamine residue, conserved in both clavaminic acid synthase isozymes 1 and 2, demonstrated that none of these residues is essential for activity.
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