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  • Title: The parathyroid hormones: bone-forming agents for treatment of osteoporosis.
    Author: Whitfield JF, Morley P, Willick GE.
    Journal: Medscape Womens Health; 2000; 5(5):E5. PubMed ID: 11113778.
    Abstract:
    This is a 3-part article. Part 1 is an overview of bone formation and resorption and the consequences of estrogen loss on bone. Part 2 comprehensively reviews the most current data on the ability of a family of potent osteoblast-stimulating bone-builders, the native 84-amino-acid parathyroid hormone (PTH), and certain of its 31- to 38- amino-acid fragments to stimulate the growth of animal and human bones. These PTHs are currently in, or about to enter, clinical trial as treatment for postmenopausal osteoporosis. Part 3 provides a detailed consideration of how these PTHs might stimulate bone growth via PTH receptor signaling.
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