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  • Title: Enhancing the intensities of lysine-terminated tryptic peptide ions in matrix-assisted laser desorption/ionization mass spectrometry.
    Author: Beardsley RL, Karty JA, Reilly JP.
    Journal: Rapid Commun Mass Spectrom; 2000; 14(23):2147-53. PubMed ID: 11114023.
    Abstract:
    Tryptic digests of three proteins are reacted with O-methylisourea in order to convert lysine residues to homoarginines. The resulting homoarginine-terminated peptides exhibit more intense MALDI mass spectral peaks than their lysine-terminated predecessors. This simple chemical reaction should therefore facilitate protein sequencing and mass mapping.
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