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  • Title: Protection of cattle against rinderpest by intranasal immunisation with a dry powder tissue culture vaccine.
    Author: Anderson J, Fishbourne E, Corteyn A, Donaldson AI.
    Journal: Vaccine; 2000 Nov 22; 19(7-8):840-3. PubMed ID: 11115707.
    Abstract:
    Dry powder tissue culture rinderpest vaccine containing 10(2.5) TCID(50) of virus per dose administered intranasally to cattle induced high titre circulating antibody responses and protection against challenge with a virulent strain of rinderpest virus. A reduction in the dose of virus to 10(1.1) TCID(50) resulted in a failure to elicit detectable antibody responses and a lack of protection. Intranasal powder vaccine offers several advantages over conventional needle-administered aqueous rinderpest vaccine, including greater stability in the absence of a cold chain, reduced risk of 'needle transfer' of other microbial agents present in the vaccinated herd and lower cost.
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