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  • Title: A truncated variant of the hepatitis C virus core induces a slow but potent immune response in mice following DNA immunization.
    Author: Dueñas-Carrera S, Alvarez-Lajonchere L, Alvarez-Obregón JC, Herrera A, Lorenzo LJ, Pichardo D, Morales J.
    Journal: Vaccine; 2000 Nov 22; 19(7-8):992-7. PubMed ID: 11115726.
    Abstract:
    Vaccination of BALB/c mice with pIDKCo, a plasmid containing the coding sequence for the first 176 amino acids of the hepatitis C virus (HCV) core protein, induced both humoral and cellular specific immune responses. Particularly, the level of anti-core antibodies increased slowly with time up to a mean value above 1:8000 that was generally superior than that found in anti-HCV positive individuals. Six out of nine anti-HCV positive human sera were able to inhibit at different extent the binding of mouse anti-core sera to a recombinant capsid protein. Our results show that it is possible to elicit a potent humoral and cellular immune response against the HCV core antigen in mice following DNA immunization.
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