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  • Title: [Qualitative features of erythropoiesis in men and animals adapted to prolonged hypoxia].
    Author: Tavrovskaia TV, Tarakanova OI, Barbashova ZI.
    Journal: Biull Eksp Biol Med; 1975 Jan; 79(1):18-21. PubMed ID: 1111636.
    Abstract:
    A three-month adaptation to hypoxia was shown to cause not only a quantitative increase in the erythropoietic bone marrow function, but also its qualitative change. This was indicated by a gradual increase in the proliferative activity of all the cells of the erythroid series, including such young cells as basophilic normoblasts and erythroblasts; an increase in the intensity of DNA synthesis; a cut of the reticulocyte maturation period and of the mean duration of erythrocyte survival in the peripheral blood. It is supposed that the whole vital cycle of erythocytres from the time of their origination in the bone marrow--to their death in the peripheral blood was accelerated.
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