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  • Title: [Study of a drug combination for topical use, with contraceptive, antibacterial and antimycotic action and venereal disease preventive action. II. Optical microscopic and scanning microscopic studies of morphological changes of human spermatozoa in vitro after contact with the oxyquinoline sulfate and copper sulfate association].
    Author: Ivaldi M, Mazzilli F, Santoro S, Crescenzi F, Santoro C.
    Journal: Minerva Ginecol; 1979 May; 31(5):387-90. PubMed ID: 111167.
    Abstract:
    A new spermicidal contraceptive agent consisting of an association of oxyquinoline sulfate and copper sulfate was tested in vitro to study its morphological effects on fresh sperm. Notable changes, such as a crumpling of the head, and variations in linear geometry of spermatozoa, were noted at the optic microscope. The scanning microscope discovered further erosions at the head and at the neck membranes level. It would be advisable to further study the association of these 2 drugs, to be eventually used as a strong topical spermicidal agent, and as a valid alternative to hormonal contraception.
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