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  • Title: Predictive value of pharmacological activity for the relative efficacy of antidepressant drugs. Meta-regression analysis.
    Author: Freemantle N, Anderson IM, Young P.
    Journal: Br J Psychiatry; 2000 Oct; 177():292-302. PubMed ID: 11116769.
    Abstract:
    BACKGROUND: There is uncertainty about the contribution of specific pharmacological properties to the efficacy of antidepressants. AIMS: To assess whether specific pharmacological characteristics of alternative antidepressants resulted in altered efficacy compared to that of selective serotonin reuptake inhibitors in the treatment of major depression. METHOD: Meta-regression analysis of randomised trials that compare treatment with a selective serotonin reuptake inhibitor and an alternative antidepressant. RESULTS: One-hundred-and-five randomised trials were included. None of the factors identified a priori predicted a statistically significant improvement in outcome across the trials. CONCLUSIONS: This analysis does not provide evidence that antidepressants acting at more than one pharmacological site differ in efficacy from drugs selective for serotonin reuptake in the treatment of major depression.
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