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  • Title: Haemolysis complicating viral hepatitis in patients with glucose-6-phosphate dehydrogenase deficiency.
    Author: Chan TK, Todd D.
    Journal: Br Med J; 1975 Jan 18; 1(5950):131-3. PubMed ID: 1111716.
    Abstract:
    Out of 20 patients with viral hepatitis whose glucose-6-phosphate dehydrogenase (G-6-PD) levels were normal, 14 had clinical evidence of a mild to moderate degree of haemolysis but in all the patients studied the half life of chromium-51-labelled red cells was shortened. Out of 18 viral hepatitis patients deficient in G-6-PD 17 had clinical evidence of haemolysis, and in eight this was more severe than in the group with normal G-6-PD values. Massive intravascular haemolysis occurred in four, three of whom died. The massive haemolysis was attributed to the presence of additional drug-induced oxidative stress to the G-6-PD-deficient red cells.
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