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  • Title: Do Ca2+ channels share NMDA receptors in plasticity of synaptic transmission in the rat visual cortex?
    Author: Salami M, Fathollahi Y.
    Journal: Neuroreport; 2000 Nov 27; 11(17):3887-91. PubMed ID: 11117509.
    Abstract:
    We examined the involvement of Ca2+ channels in LTP of responses in rat visual cortex slices. Stimulating layer IV, field potentials including EPSP1 and EPSP2 from layer II/III were recorded. L-type Ca2+ channel blocker nifedipine did not have a considerable effect on LTP of the responses. T-type Ca2+ channel blocker Ni2+ decreased potentiation of EPSP1 and almost blocked that of EPSP2. Effect of visual experience on the function of the channels is also considered. These results indicate that T-type Ca2+ channels play a real role in stable LTP of EPSP2. Also the function of the channels was almost the same in dark and light reared visual cortices.
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