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  • Title: Sex hormone-binding globulin during puberty in normal and hyperandrogenic girls.
    Author: Pugeat M, Cousin P, Baret C, Lejeune H, Forest MG.
    Journal: J Pediatr Endocrinol Metab; 2000; 13 Suppl 5():1277-9. PubMed ID: 11117669.
    Abstract:
    Human sex hormone-binding globulin (SHBG) regulates the cellular bioavailability of SHBG-bound steroid hormones. Subtle decreases in plasma SHBG levels during puberty have a perceptible effect on the androgen-estrogen balance. This SHBG decrease is more pronounced in girls with premature pubarche who are at risk to develop functional ovarian hyperandrogenism as well as insulin resistance syndrome. Insulin is a potent inhibitor of SHBG production in the liver, and there is now evidence that SHBG is a marker of hyperinsulinemia and insulin resistance that can be associated in both obese and non-obese patients with polycystic ovary syndrome. Therefore, low SHBG could be a useful tool for identifying presymptomatic individuals with diabetes mellitus type 2 including those with androgen disorders.
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