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  • Title: Choosing a route of administration for quadrivalent meningococcal polysaccharide vaccine: intramuscular versus subcutaneous.
    Author: Ruben FL, Froeschle JE, Meschievitz C, Chen K, George J, Reeves-Hoché MK, Pietrobon P, Bybel M, Livingood WC, Woodhouse L.
    Journal: Clin Infect Dis; 2001 Jan; 32(1):170-2. PubMed ID: 11118395.
    Abstract:
    A clinical trial was conducted to compare intramuscular (im) with subcutaneous (sc) routes for administration of quadrivalent meningococcal polysaccharide vaccine in 141 adults. Safety assessment showed the im route had reduced erythema (P<.01) and reduced headache on days 1 and 2 (P<.05). Serological testing for serum bactericidal antibody titers against capsular groups A and C did not detect significant differences.
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