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  • Title: Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae.
    Author: Depardieu F, Courvalin P.
    Journal: Antimicrob Agents Chemother; 2001 Jan; 45(1):319-23. PubMed ID: 11120988.
    Abstract:
    Streptococcus pneumoniae clinical isolate BM4455 was resistant to 16-membered macrolides and to streptogramins. This unusual resistance phenotype was due to an A(2062)C (Escherichia coli numbering) mutation in domain V of the four copies of 23S rRNA.
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