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  • Title: The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase.
    Author: Haraguchi K, Satoh K, Yanai H, Hamada F, Kawabuchi M, Akiyama T.
    Journal: Genes Cells; 2000 Nov; 5(11):905-911. PubMed ID: 11122378.
    Abstract:
    BACKGROUND: Postsynaptic density (PSD)-95 interacts with and mediates clustering of the N-methyl-D-aspartate-receptors (NMDA-R). PSD-95 also interacts with the hDLG-associated protein DAP, which is also called Synapse-associated protein 90-associated protein (SAPAP), and Guanylate kinase-associated protein (GKAP). RESULTS: DAP interacted directly with the dynein light chain (DLC) family of proteins. DLC was contained in the NMDA-R-PSD-95-DAP-neuronal nitric oxide synthase (nNOS) complex. Furthermore, DAP interacted with nNOS and recruited it into the Triton X-100-insoluble fraction of transfected cells. CONCLUSION: DAP interacts directly with DLC and nNOS, and links these proteins to the NMDA-R-PSD-95 complex.
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