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  • Title: Spontaneous intracranial bleeding in two patients with congenital afibrinogenaemia and the role of replacement therapy.
    Author: Parameswaran R, Dickinson JP, de Lord S, Keeling DM, Colvin BT.
    Journal: Haemophilia; 2000 Nov; 6(6):705-8. PubMed ID: 11122402.
    Abstract:
    Congenital afibrinogenaemia and hypofibrinogenaemia are rare disorders of haemostasis. In this case report the problems posed in the management of two patients with fibrinogen levels less than 0.1g L(-1) and who developed intracranial bleeding are considered. The value of fibrinogen concentrate and the role of prophylaxis is also discussed.
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