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  • Title: Unusual manifestations of type II cryoglobulinaemia associated with Waldenström's macroglobulinaemia.
    Author: Blanco P, Viallard JF, Rivel J, Leng B, Pellegrin JL.
    Journal: J Clin Pathol; 2000 Nov; 53(11):882-4. PubMed ID: 11127277.
    Abstract:
    Cryoglobulinaemia in association with Waldenström's macroglobulinaemia is relatively common, ranging from 8% to 18% of cases; however, < 5% have symptoms or complications. We describe a patient with a history of cutaneous, peritoneal, and fallopian tube vasculitis related to type II cryoglobulinaemia associated with Waldenström's macroglobulinaemia. Cytotoxic treatment was initiated (cyclophosphamide, vincristine, and prednisone) and had a good initial response. However, after the third course of chemotherapy, the patient presented with septic shock and died. Even though cryoglobulinaemia is a model of systemic vasculitis, peritoneal and fallopian tube vasculitis associated with type II cryoglobulinemia has not been described previously.
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