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  • Title: Egasyn, a protein complexed with microsomal beta-glucuronidase.
    Author: Tominco S, Paigen K.
    Journal: J Biol Chem; 1975 Feb 10; 250(3):1146-8. PubMed ID: 1112792.
    Abstract:
    Two polypeptide chains are present in murine beta-glucuronidase precipitated with a specific anti-beta-glucuronidase antibody F(ab)2 fragment. One is the catalytic subunit of beta-glucuronidase and the other has the properties predicted for the hypothetical beta-gluronidase membrane anchor protein. The new protein, named egasyn, is associated with microsomal, but no lysosomal beta-glucuronidase. It is released from the microsomal beta-glucuronidase complex by heat treatment. The YBR strain of mice carrying the Eg degrees mutation does not form an egasyn-beta-glucuronidase complex and is unable to retain beta-glucuronidase on microsomal membranes.
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