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  • Title: Tc-99m PMT whole-body scintigraphy for evaluated of therapeutic effect and for monitoring bone metastasis in a patient with hepatocellular carcinoma.
    Author: Sueyoshi K, Narabayashi I, Doi K, Takahashi M, Komori T, Tatsu Y, Tatsumi T, Utunomiya K, Uesugi Y, Adachi I, Shimizu T.
    Journal: Clin Nucl Med; 2000 Dec; 25(12):1000-3. PubMed ID: 11129132.
    Abstract:
    Detection of metastatic lesions by bone scintigraphy is highly sensitive but has a low rate of specificity. Often bone metastases from hepatocellular carcinoma are not detected by bone scintigraphy because of low uptake or a photopenic area in the tumor. In contrast, Tc-99m Sn-N-pyridoxy-5-methyltryptophan (Tc-99m PMT) whole-body scintigraphy reflects tumor viability, and the specificity of detection is so high that tumor structure can be shown well. Tc-99m PMT whole-body scintigraphy was helpful for evaluating the response to therapy and monitoring the course of the patient described here with bone metastasis from hepatocellular carcinoma.
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