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  • Title: Effect of recombinant human granulocyte colony stimulating factor on lymphocyte blastogenesis in healthy dogs.
    Author: Hasegawa T, Inomata T.
    Journal: J Vet Med Sci; 2000 Nov; 62(11):1205-7. PubMed ID: 11129867.
    Abstract:
    Effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on the number and blastogenesis of lymphocytes were evaluated in clinically healthy dogs treated subcutaneously with rhG-CSF at a dose of 2.5 microg/kg for 3 days. Significant increases in the number of leukocytes and segmented neutrophils were observed after the administration of rhG-CSF. The number of lymphocytes also increased on days 1 and 2 after the treatment. Activities of phytohemagglutinin, concanavalin A, and pokeweed mitogen-induced lymphocyte blastogenesis (LB) were augmented to twice the pretreatment levels by the administration of rhG-CSF. These results suggested that administration of rhG-CSF activated lymphocyte functions such as LB in healthy dogs.
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