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  • Title: [Neurobiological aspects of the etiology and pathophysiology of obsessive-compulsive disorder].
    Author: Kordon A, Hohagen F.
    Journal: Psychother Psychosom Med Psychol; 2000 Nov; 50(11):428-34. PubMed ID: 11130143.
    Abstract:
    Obsessive-compulsive disorder (OCD) is a common psychiatric illness characterized by intrusive, repetitive thoughts and behaviours which cause marked distress. During the last decade, different models were developed for the pathophysiology of the obsessive-compulsive-disorder. Three different neurobiological models are introduced in this article: 1. model of dysfunctional kortikostriatal circuitry, 2. amygdalocentric model, 3. neurochemical model. These models don't exclude themselves mutually but supplement themselves and should ideally be integrated into a biopsychosocial concept. Such increased understanding of the neurobiology can be translated into better diagnosis and treatment for those patients who suffer from obsessive-compulsive-disorder.
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