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  • Title: Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7.
    Author: Höpfl R, Heim K, Christensen N, Zumbach K, Wieland U, Volgger B, Widschwendter A, Haimbuchner S, Müller-Holzner E, Pawlita M, Pfister H, Fritsch P.
    Journal: Lancet; 2000 Dec 09; 356(9246):1985-6. PubMed ID: 11130532.
    Abstract:
    We investigated delayed-type hypersensitivity to human papillomavirus (HPV) in women with cervical dysplasia or cancer. Women were challenged by skin tests with synthetic HPV-16 E7 oncoprotein peptides. 11 women were regressors (cleared disease without treatment) and 37 were progressors (required surgery). Antibodies to early antigens (markers for progression) were detectable in a higher proportion of cancer patients than all other patients, particularly progressors with cervical intraepithelial neoplasia (CIN). By contrast, cellular immunity to HPV-16 E7, measured by skin test, was significantly (p=0.0001) associated with clinical and cytological resolution of HPV-induced CIN, indicating that E7-specific T-helper cells have a role in control of HPV.
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