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  • Title: Venlafaxine XR in the treatment of anxiety.
    Author: Hackett D.
    Journal: Acta Psychiatr Scand Suppl; 2000; (406):30-5. PubMed ID: 11131468.
    Abstract:
    OBJECTIVE: To present the results of numerous studies that assessed the efficacy, safety and tolerability of venlafaxine extended release (XR) in treating anxiety disorders, particularly generalized anxiety disorder (GAD). METHOD: Efficacy was assessed with the Hamilton Rating Scale for Anxiety, Clinical Global Impressions scale, Hospital Anxiety and Depression scale and other instruments. Standard safety and tolerability assessments were used. RESULTS: In four placebo-controlled trials, venlafaxine XR was effective and well tolerated in patients with GAD. Several additional smaller studies found venlafaxine XR effective in treating anxiety associated with social phobia, obsessive-compulsive disorder and panic disorder. CONCLUSION: Venlafaxine XR has both short- and long-term efficacy and tolerability in treating symptoms of long-term anxiety and comorbid anxiety and depression, and in achieving remission in GAD patients. These characteristics, combined with early onset of anxiolytic action and dose response effect, make it a logical choice for treating anxiety occurring alone or comorbidly with depression.
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