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  • Title: 2-Aryl tryptamines: selective high-affinity antagonists for the h5-HT2A receptor.
    Author: Stevenson GI, Smith AL, Lewis S, Michie SG, Neduvelil JG, Patel S, Marwood R, Patel S, Castro JL.
    Journal: Bioorg Med Chem Lett; 2000 Dec 18; 10(24):2697-9. PubMed ID: 11133071.
    Abstract:
    A series of 2-aryl tryptamines have been identified as high-affinity h5-HT2A antagonists. Structure-activity relationship studies have shown that h5-HT2A affinity can be attained via modifications to the tryptamine side chain and that selectivity over h5-HT2C and hD2 receptors can be controlled by suitable C-2 aryl groups.
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