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  • Title: 1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase.
    Author: Lee Y, Martásek P, Roman LJ, Silverman RB.
    Journal: Bioorg Med Chem Lett; 2000 Dec 18; 10(24):2771-4. PubMed ID: 11133088.
    Abstract:
    1H-Pyrazole-1-carboxamidines were prepared as potential inhibitors of the three isozymes of nitric oxide synthase. All of the compounds were found to be competitive inhibitors of all three isoforms. The most selective compound prepared was 1H-pyrazole-N-(3-aminomethylanilino)-1-carboxamidine (14), which is 100-fold selective for nNOS over eNOS with a Ki value of 2 microM.
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