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  • Title: Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors.
    Author: Zhang N, Wu B, Powell D, Wissner A, Floyd MB, Kovacs ED, Toral-Barza L, Kohler C.
    Journal: Bioorg Med Chem Lett; 2000 Dec 18; 10(24):2825-8. PubMed ID: 11133101.
    Abstract:
    A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50's against MAP kinase kinase, and have potent inhibitory activity in tumor cells.
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