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  • Title: Matrical inclusions induced by clofibrate in hepatic microbodies of rats fed 2-acetylaminofluorene.
    Author: Tsukada H, Mochizuki Y, Gotoh M.
    Journal: J Natl Cancer Inst; 1975 Feb; 54(2):519-23. PubMed ID: 1113332.
    Abstract:
    Abnormal inclusions in microbodies were induced by clofibrate in hepatocytes of hyperplastic liver nodules in rats fed 2-acetylaminofluorene. These were matrical tubules and plates, each with the same ultrastructural features as those reported previously by other investigators. A hyperplastic state of hepatocytes induced by hepatocarcinogens might be related to the formation of these inclusions in response to clofibrate.
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