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  • Title: Bipotential B-macrophage progenitors are present in adult bone marrow.
    Author: Montecino-Rodriguez E, Leathers H, Dorshkind K.
    Journal: Nat Immunol; 2001 Jan; 2(1):83-8. PubMed ID: 11135583.
    Abstract:
    According to the current model of adult hematopoiesis, differentiation of pluripotential hematopoietic stem cells into common myeloid- and lymphoid-committed progenitors establishes an early separation between the myeloid and lymphoid lineages. This report describes a rare and previously unidentified CD45R-CD19+ B cell progenitor population in postnatal bone marrow that can also generate macrophages. In addition to the definition of this B-lineage intermediate, the data indicate that a developmental relationship between the B and macrophage lineages is retained during postnatal hematopoiesis.
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