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  • Title: [Changes of hepatic energy metabolism following partial hepatopetal blood occlusion].
    Author: He X, Dong J, Cai J, Li K, Duan H, Han B.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 2000 Dec; 8(6):358-60. PubMed ID: 11135697.
    Abstract:
    OBJECTIVE: To evaluate the changes of hepatic energy metabolism by temporary occlusion of partial hepatopetal blood. METHODS: The animal mode of partial hepatopetal blood occlusion (PBO) was established without portal stasis. The hepatic energy metabolism parameters including adenosine triphosphate, respiratory control ratio, P/O ratio, and arterial ketone bodies ratio were studied following 30 min ischemia or 1, 6, and 24 h of reperfusion. The total hepatopetal blood occlusion (TBO) and sham groups served as control. RESULTS: The parameters of hepatic motochondrial function reflecting hepatic damage to ischemia-reperfusion showed different in PBO comparing with TBO group. The functional lesion was restored progressively in PBO-30 min group, but it was maintained low level in TBO-30 min group. CONCLUSION: The results suggest that it is beneficial to restoration of the hepatic energy metabolism in the ischemia-reperfusion injury by partial hepatopetal blood occlusion.
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