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  • Title: Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice.
    Author: Parnaud G, Taché S, Peiffer G, Corpet DE.
    Journal: Br J Cancer; 2001 Jan 05; 84(1):90-3. PubMed ID: 11139319.
    Abstract:
    Polyethylene-glycol (PEG) is a strong inhibitor of colon cancer in rats, and the most potent suppressor of aberrant crypt foci. 9 PEG-like block copolymers were tested in rodents, after an azoxymethane injection. Dietary pluronic F68 led to a 98.6% reduction in the number of aberrant crypt foci in a first rat study (P< 0.0001). Next 3 studies confirmed this pluronic efficacy in rats and mice. This non-toxic laxative seems roughly 5 times more potent than PEG for chemoprevention.
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