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  • Title: [Amniotic fluid leakage and premature rupture of membranes after amniocentesis. A review of the literature].
    Author: Abboud P, Zejli A, Mansour G, Monnoyer Y, Houareau LG, Bart H, Bock S.
    Journal: J Gynecol Obstet Biol Reprod (Paris); 2000 Dec; 29(8):741-745. PubMed ID: 11139709.
    Abstract:
    BACKGROUND: Amniotic fluid leakage and premature rupture of membranes following amniocentesis is uncommon. MATERIAL AND METHODS: We reviewed the literature. Thirteen recent studies including 17 186 amniocenteses and 280 cases of amniotic fluid leakage were analyzed. RESULTS AND DISCUSSION: Risk increases when early amniocentesis is performed prior to 15 weeks gestation and when the needle is inserted far from the placenta. Significant loss of amniotic fluid compromises pregnancy. Conservative management with bed rest seems to give good results. When amniotic leakage persists for more than two weeks, there is little spontaneous resolution. The risk of pursuing the pregnancy should be discussed with the couple in this case. Risks include respiratory disorders, skeletal malformations and premature birth. CONCLUSION: New techniques such as 'amniopatch' may play an important role in the near future.
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