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  • Title: Sesquiterpene lactones from Centaurea thessala and Centaurea attica. Antifungal activity.
    Author: Skaltsa H, Lazari D, Panagouleas C, Georgiadou E, Garcia B, Sokovic M.
    Journal: Phytochemistry; 2000 Dec; 55(8):903-8. PubMed ID: 11140522.
    Abstract:
    The aerial parts of Centaurea thessala ssp. drakiensis and C. attica ssp. attica afforded, in addition to several known sesquiterpene lactones, two new eudesmanolides, 4-epi-sonchucarpolide and its 8-(3-hydroxy-4-acetoxy-2-methylene-butanoyloxy) derivative and one new eudesmane derivative, named atticin. The in vitro antifungal activity of most compounds was tested against nine fungal species, using the micro-dilution method. All the compounds tested showed great antifungal activity.
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