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  • Title: Impairment in a discrimination reversal task after D1 receptor blockade in the pigeon "prefrontal cortex".
    Author: Diekamp B, Kalt T, Ruhm A, Koch M, Güntürkün O.
    Journal: Behav Neurosci; 2000 Dec; 114(6):1145-55. PubMed ID: 11142646.
    Abstract:
    Dopamine (DA) is known to modulate cognitive functions of the prefrontal cortex (PFC) of mammals, especially via D1 receptor mechanisms. Like the PFC, the neostriatum caudolaterale (NCL) of birds is characterized by dopaminergic input, and NLC and PFC lesions cause similar deficits. The significance of DA in a color discrimination reversal was assessed by evaluating the effects of bilateral infusions of the D1 receptor antagonist SCH 23390 into the NCL of pigeons (Columba livia). Reversal deficits were qualitatively similar to those in mammals. At a low dose, perseveration occurred predominantly to the incorrect stimulus. Higher doses caused additional spatial perseveration. The data demonstrate, for the first time, that D1 receptor mechanisms in the NCL of pigeons contribute substantially to its function in cognitive processes. Thus, the avian NCL and mammalian PFC could represent functionally equivalent neural networks under control of the DA system.
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