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  • Title: Intraventricular injection of tachykinin NK3 receptor agonists suppresses the ingestion of NaCl-associated tastes.
    Author: Flynn FW.
    Journal: Behav Neurosci; 2000 Dec; 114(6):1223-8. PubMed ID: 11142654.
    Abstract:
    The present experiments evaluated whether a salty taste was required for injections of a neurokinin-3 (NK3) receptor agonist (senktide) to suppress intake or whether senktide would reduce the intake of tastes that are predictive of NaCl. During training, different groups of rats were given access to 1% almond + water, 1% almond + 0.3 M NaCl, or 1% almond + 0.1 M sucrose. On the test day, rats were administered intraventricular injections of either saline or 200 ng senktide and then given access to 1% almond + water. Senktide had no effect on the intake of the water-associated or sucrose-associated almond. In contrast, senktide significantly reduced the intake of NaCl-associated almond. Senktide had no effect on almond intake by water-deprived rats. These results show that activation of NK3 receptors reduces the intake of NaCl and of a neutral taste that is predictive of sodium but not of calories.
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