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  • Title: A study to assess the plaque inhibitory action of a newly formulated triclosan toothpaste.
    Author: Moran J, Addy M, Newcombe RG, Marlow I.
    Journal: J Clin Periodontol; 2001 Jan; 28(1):86-9. PubMed ID: 11142672.
    Abstract:
    BACKGROUND/AIMS: Triclosan containing toothpastes have been noted for their potential to inhibit plaque and gingival inflammation. The aim of this study was to determine whether a toothpaste containing triclosan and an enhanced fluoride system would inhibit de novo plaque formation beyond that of a non-triclosan, conventional fluoride toothpaste. METHODS: This study used a 4-day plaque regrowth model in which 24 volunteers used toothpaste rinses as the only form of oral hygiene. Following a prophylaxis and a single brushing with the toothpastes, 2x daily rinsing with toothpaste slurries was used over the following 96 h. RESULTS: After 24 h, there was no difference in plaque area between the triclosan paste and its control paste. After 96 h, a reduction in plaque score of 5% was noted for the test toothpaste compared to the control paste which was statistically significant (p=0.028). For plaque area this reduction was increased to 16%, which was also significant (p=0.006). CONCLUSIONS: These findings would appear to warrant further investigation into the potential value of the paste in inhibiting both plaque and gingivitis.
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